Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression – A Randomized Controlled Trial

Objective: This study aimed to assess the antidepressant effects of subanesthetic doses of ketamine in patients with treatment-resistant depression (TRD), focusing on the impact of a single ketamine infusion, a series of repeated infusions, and the maintenance of response with ongoing infusions. Methods: Forty-one participants with TRD completed a randomized, double-blind crossover trial comparing single […]

Long-Term Effects of Repeated Ketamine Infusions for Comorbid PTSD and Treatment-Resistant Depression

Objective: This study investigated the effectiveness, safety, and lasting effects of repeated ketamine infusions for treating comorbid posttraumatic stress disorder (PTSD) and treatment-resistant depression (TRD) in a group of veterans. Methods: Fifteen individuals diagnosed with both DSM-5-defined PTSD and DSM-IV-defined major depressive disorder received six intravenous ketamine infusions (0.5 mg/kg) on Mondays, Wednesdays, and Fridays […]

Scientific Literature – American Society of Ketamine Physicians, Psychotherapists, and Practitioners

Ketamine was introduced into clinical practice in the 1960s and continues to be both clinically useful and scientifically intriguing. With its diverse molecular targets and neurophysiological properties, ketamine’s effects on the central nervous system remain incompletely understood. Researchers have utilized ketamine’s unique characteristics to investigate fundamental mechanisms of anesthetic action. Recent evidence suggests that ketamine-induced […]

Ketamine in Bipolar Disorder: A Promising Frontier in Treatment

Bipolar disorder (BD) stands as one of the most debilitating psychiatric conditions, affecting over 1% of the global population. Characterized by recurrent episodes of mania and depression, BD carries with it significant morbidity, mortality, and a heightened risk of suicide compared to other psychiatric disorders. Current treatment options, particularly for bipolar depression, often fall short […]

Immediate and Persistent Antidepressant Effects of Repeated Ketamine Infusions in Treatment-Resistant Major Depression

Ketamine is recognized for its rapid antidepressant effects, yet little is known about its impact beyond a single infusion. A previous study involving 10 individuals with treatment-resistant major depression (TRD) indicated that six ketamine infusions resulted in sustained antidepressant effects. In this updated report, we investigate the pattern and durability of these effects in a […]

Understanding Suicidality and the Role of Ketamine Therapy in Rapid Relief

Woman sits on fallen leaves in a forest.

The Complexities of Suicidality Suicidality can stem from a variety of factors, including mental health disorders like depression, anxiety, and post-traumatic stress disorder (PTSD). Other contributing factors may include chronic pain, substance abuse, and traumatic life events such as loss or abuse. For many individuals, suicidality can feel like the only way to escape overwhelming […]

Healing Scars: Exploring Ketamine Therapy for PTSD

Illustration of human head with question marks coming out of the top.

Introduction:  Traditional treatments, while effective for many, may not always provide the relief needed. In recent years, there has been growing interest in Ketamine Therapy as a potential breakthrough in addressing PTSD. Understanding PTSD: PTSD can develop after exposure to a traumatic event, causing persistent symptoms such as intrusive memories, nightmares, hypervigilance, and emotional numbness. […]

Unlocking Hope: The Promise of Ketamine Therapy in Treating Depression

Illustration of human brain.

Understanding Ketamine: Ketamine, originally developed as an anesthetic, has gained attention for its rapid-acting antidepressant properties. Unlike traditional antidepressants, which may take weeks to show results, ketamine can produce noticeable improvements within hours. Mechanism of Action: Ketamine works by targeting the glutamate system in the brain, specifically the N-methyl-D-aspartate (NMDA) receptors. This unique mechanism sets […]

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